Induction of malignant bone tumors in rats by 1-(2-hydroxyethyl)-1-nitrosourea.

  title={Induction of malignant bone tumors in rats by 1-(2-hydroxyethyl)-1-nitrosourea.},
  author={A. Pelfrene and S. Mirvish and B. Gold},
  journal={Journal of the National Cancer Institute},
  volume={56 2},
  • A. Pelfrene, S. Mirvish, B. Gold
  • Published 1976
  • Medicine
  • Journal of the National Cancer Institute
  • Forty male MRC-W rats were treated chronically with 1-(2-hydroxyethyl)-1-nitrosourea in drinking water (total dose, 330 mg/rat). Fifteen rats (38%) developed osteogenic osteosarcomas or chondrosarcomas of the lower vertebrae. This was the first time that an orally administered organic compound induced a high incidence of these tumors. 
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