Induction of macrophage VEGF in response to oxidized LDL and VEGF accumulation in human atherosclerotic lesions.

  • M A Ramos, M Kuzuya, +6 authors A Iguchi
  • Published 1998 in
    Arteriosclerosis, thrombosis, and vascular…
The interaction between macrophages and oxidatively modified low density lipoprotein (Ox-LDL) appears to play a central role in the development of atherosclerosis, not only through foam cell formation but also via the induction of numerous cytokines and growth factors. The current study demonstrated that Ox-LDL upregulated vascular endothelial growth factor… (More)