Induction of macrophage Ia expression in vivo by a synthetic block copolymer, L81.

@article{Howerton1990InductionOM,
  title={Induction of macrophage Ia expression in vivo by a synthetic block copolymer, L81.},
  author={D A Howerton and Robert Lee Hunter and H. Kirk Ziegler and Irene J. Check},
  journal={Journal of immunology},
  year={1990},
  volume={144 5},
  pages={1578-84}
}
Certain synthetic, nonionic, block copolymers of polyoxypropylene and polyoxyethylene are potent immunoadjuvants. While investigating their mechanisms of action, we found that one of these copolymers, L81, induced the expression of macrophage Ia in vivo. L81 is a 2750-Da, linear copolymer with a 43-unit core of hydrophobic polyoxypropylene flanked on each side by 3 U of hydrophilic polyoxyethylene. It induced threefold to sevenfold increases in the proportion of peritoneal macrophages… CONTINUE READING

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