Induction of lysophosphatidic acid receptor-3 by 12-O-tetradecanoylphorbol-13-acetate stimulates cell migration of rat liver cells.

@article{Okabe2011InductionOL,
  title={Induction of lysophosphatidic acid receptor-3 by 12-O-tetradecanoylphorbol-13-acetate stimulates cell migration of rat liver cells.},
  author={Kyoko Okabe and Kohei Kato and Miki Teranishi and Mai Okumura and Rie Fukui and Toshio Mori and Nobuyuki Fukushima and Toshifumi Tsujiuchi},
  journal={Cancer letters},
  year={2011},
  volume={309 2},
  pages={
          236-42
        }
}
12-O-tetradecanoylphorbol-13-acetate (TPA) which is one of tumor promoting agents stimulates cell migration ability of several tumor cells. In the present study, we investigated whether lysophosphatidic acid (LPA) receptors are involved in cell migration of rat liver cells stimulated by TPA. The rat liver epithelial WB-F344 and hepatoma RH7777 cells were treated by TPA for 48h. The expression levels of LPA receptor genes in those cells were measured by real-time reverse transcription (RT… CONTINUE READING
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