Induction of lung CD8+ T cell responses by consecutive inoculations of a poly(I:C) influenza vaccine.

Abstract

The cytotoxic T lymphocyte (CTL) response plays a key role in host recovery from influenza virus infection and in subsequent immunity. Compared to natural infection with influenza virus, however, intranasal vaccination with adjuvant-combined inactivated vaccine elicits only moderate CTL responses. Here we demonstrate that 5 days of consecutive, intranasal… (More)
DOI: 10.1016/j.vaccine.2017.10.038

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