Induction of long-term potentiation in single nociceptive dorsal horn neurons is blocked by the CaMKII inhibitor AIP.

@article{Pedersen2005InductionOL,
  title={Induction of long-term potentiation in single nociceptive dorsal horn neurons is blocked by the CaMKII inhibitor AIP.},
  author={Linda Margareth Pedersen and Guro Flor Lien and Ingunn Bollerud and Johannes Gjerstad},
  journal={Brain research},
  year={2005},
  volume={1041 1},
  pages={66-71}
}
Neuronal events leading to development of long-term potentiation (LTP) in the nociceptive pathways may be a cellular mechanism underlying central hyperalgesia. Here, we examine whether induction of LTP in nociceptive dorsal horn neurons at depths of 80-500 microm from the cord surface can be affected by spinal application of the Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) inhibitor AIP. Extracellular recordings from single neurons in intact urethane anesthetized Sprague-Dawley rats… CONTINUE READING