Induction of long-term potentiation at hippocampal mossy-fiber synapses follows a Hebbian rule.

@article{Jaffe1990InductionOL,
  title={Induction of long-term potentiation at hippocampal mossy-fiber synapses follows a Hebbian rule.},
  author={David B. Jaffe and Daniel Johnston},
  journal={Journal of neurophysiology},
  year={1990},
  volume={64 3},
  pages={948-60}
}
1. The induction of long-term potentiation (LTP) at hippocampal mossy-fiber synapses requires an increase in postsynaptic [Ca2+]i but is independent of N-methyl-D-aspartate (NMDA) receptor activation. Voltage-gated Ca2+ channels have been proposed as one alternative source for raising [Ca2+]i during the induction of LTP. We tested the hypothesis that voltage-gated Ca2+ channel activation could mediate the induction of LTP by examining whether 1) the induction of mossy-fiber LTP was dependent on… CONTINUE READING