Induction of long-lasting immunity to Plasmodium yoelii malaria with whole blood-stage antigens and copolymer adjuvants.

@article{Hunter1995InductionOL,
  title={Induction of long-lasting immunity to Plasmodium yoelii malaria with whole blood-stage antigens and copolymer adjuvants.},
  author={Robert L. C. Hunter and Michael R. Kidd and Margaret R Olsen and Paige Patterson and A. Ashirbadi Lal},
  journal={Journal of immunology},
  year={1995},
  volume={154 4},
  pages={
          1762-9
        }
}
We previously reported that protection of mice from nonlethal Plasmodium yoelii malaria by immunization with whole killed blood-stage parasites was dependent on the adjuvant and that adjuvants influenced both the specificity and isotype of Ab. Additional studies with the most effective formulations were undertaken to better define the protective responses and 100% protection from lethal P. yoelii malaria was produced by three immunizations with Ag in copolymer P1004 and detoxified RaLPS as… CONTINUE READING

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