Induction of liver cytochrome P4502E1 by pyrazole and 4-methylpyrazole in neonatal rats.

@article{Wu1993InductionOL,
  title={Induction of liver cytochrome P4502E1 by pyrazole and 4-methylpyrazole in neonatal rats.},
  author={Defeng Wu and Arthur I. Cederbaum},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1993},
  volume={264 3},
  pages={1468-73}
}
Cytochrome P4502E1 (P4502E1) is not present in fetal rat liver; activation of the gene occurs within hours after birth. In adult rats, chemical inducers increase P4502E1 levels largely by a post-transcriptional type of mechanism. Experiments were carried out to evaluate how soon after birth chemicals such as pyrazole or 4-methylpyrazole (MP) can induce P4502E1 and whether the mechanism for induction at these early developmental stages, during active transcription, is different from that found… CONTINUE READING

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