Induction of lipogenesis in white fat during cold exposure in mice: link to lean phenotype

@article{Flachs2017InductionOL,
  title={Induction of lipogenesis in white fat during cold exposure in mice: link to lean phenotype},
  author={Pavel Flachs and Katerina Adamcova and Petr Zouhar and Carlos Marques and Petra Janovska and Ivan Viegas and J G Jones and Kristina Bardova and M. Svobodova and Jana Hans{\'i}kov{\'a} and Ondřej Kuda and Martin Rossmeisl and Ulrike Liisberg and Alison G Borkowska and Karsten Kristiansen and Lise Madsen and Jan Kopeck{\'y}},
  journal={International Journal of Obesity},
  year={2017},
  volume={41},
  pages={372-380}
}
Background/objective:Futile substrate cycling based on lipolytic release of fatty acids (FA) from intracellular triacylglycerols (TAG) and their re-esterification (TAG/FA cycling), as well as de novo FA synthesis (de novo lipogenesis (DNL)), represent the core energy-consuming biochemical activities of white adipose tissue (WAT). We aimed to characterize their roles in cold-induced thermogenesis and energy homeostasis.Methods:Male obesity-resistant A/J and obesity-prone C57BL/6J mice maintained… Expand
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