Induction of lipid peroxidation in tissues of thallous malonate-treated hamster.

@article{Aoyama1988InductionOL,
  title={Induction of lipid peroxidation in tissues of thallous malonate-treated hamster.},
  author={H Aoyama and M. Yoshida and Yukio Yamamura},
  journal={Toxicology},
  year={1988},
  volume={53 1},
  pages={
          11-8
        }
}
Toxicity of thallium on isolated rat liver mitochondria: The role of oxidative stress and MPT pore opening
TLDR
The data strongly supported that the thallium(I)‐induced liver toxicity is a result of the disruptive effect of this metal on the mitochondrial respiratory complexes (I, II, and IV), which are the obvious causes of metal‐induced ROS formation and ATP depletion.
In vitro Interactions of Thallium with Components of the Glutathione-dependent Antioxidant Defence System
TLDR
The present results show that Tl interacts with all the components of GSH/GSSG antioxidant defence system, and Alterations of this protective pathway could be partially responsible for the oxidative stress associated with Tl toxicity.
Endogenous thiols enhance thallium toxicity
TLDR
Results indicate that L-met and L-cys administered alone or in combination with PB should not be considered suitable treatments against acute Tl toxic effects because this strategy failed to prevent mortality and Tl accumulation in brain.
Vitamin E and C in the prevention of metal nephrotoxicity in developing rats.
  • D. Appenroth, K. Winnefeld
  • Biology, Medicine
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
  • 1998
A comparison of hepatocyte cytotoxic mechanisms for thallium (I) and thallium (III)
TLDR
Both Tl (I) and Tl(III) cytotoxicities were associated with mutual mitochondrial/lysosomal injuries (cross‐talk) initiated by increased ROS formation resulted from metal‐CYP2E1 destructive interaction or metal‐induced disruption of mitochondrial electron transfer chain.
Study of acute biochemical effects of thallium toxicity in mouse urine by NMR spectroscopy
TLDR
The present study indicates the great potential of NMR‐based metabonomics in mapping metabolic response for toxicology, which could ultimately lead to identification of potential markers for Tl toxicity.
Delayed effects of thallium in the rat brain: regional changes in lipid peroxidation and behavioral markers, but moderate alterations in antioxidants, after a single administration.
Oxidative stress and DNA damage in broad bean (Vicia faba L.) seedlings induced by thallium
TLDR
Results obtained indicate that oxidative stress is involved in the mechanism of Tl toxicity and that the tolerance of broad bean to Tl is achieved, at least in part, through the increased activity of antioxidant enzymes.
Thallium(I) and thallium(III) induce apoptosis in isolated rat hepatocytes by alterations in mitochondrial function and generation of ROS
Environmental metal toxins, generated through diverse anthropogenic activities, constitute one of the major contaminants that have led to global dispersion of these toxic metals in the ecosystem.
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