Induction of leukotriene production by bleomycin and asparaginase in mast cells in vitro and in patients in vivo.

@article{Geuenich1998InductionOL,
  title={Induction of leukotriene production by bleomycin and asparaginase in mast cells in vitro and in patients in vivo.},
  author={S Geuenich and Christopher Haberl and Daniel Egger and Uwe Kaspers and Lothar H{\"u}ltner and Wolfgang Wilmanns and Claudio Denzlinger},
  journal={Biochemical pharmacology},
  year={1998},
  volume={55 4},
  pages={447-53}
}
Bleomycin and asparaginase are widely used antineoplastic agents which may induce allergic or inflammatory side-effects. Mast cells are implicated as effector cells in allergic and inflammatory responses. The aim of this study was to establish whether bleomycin or asparaginase modulate leukotriene production in vitro and in vivo. Leukotriene C4 (LTC4) production by murine bone marrow-derived mast cells (BMMC) was determined by radioimmunoassay (RIA). Leukotriene production in patients was… CONTINUE READING