Induction of lectin-like transcript 1 (LLT1) protein cell surface expression by pathogens and interferon-γ contributes to modulate immune responses.

@article{Germain2011InductionOL,
  title={Induction of lectin-like transcript 1 (LLT1) protein cell surface expression by pathogens and interferon-γ contributes to modulate immune responses.},
  author={Claire Germain and Anders Meier and Teis Jensen and Perrine Knapnougel and Gw{\'e}nola Poupon and Anne Lazzari and Anne Neisig and Katarina H{\aa}kansson and Tao Dong and Nicolai R Wagtmann and Elizabeth D Galsgaard and Pieter Spee and V{\'e}ronique M Braud},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 44},
  pages={37964-75}
}
CD161 is a C-type lectin-like receptor expressed on human natural killer (NK) cells and subsets of T cells. CD161 has been described as an inhibitory receptor that regulates NK cell-mediated cytotoxicity and IFN-γ production. Its role on T cells has remained unclear. Studies have shown that triggering of CD161 enhances NK T cell proliferation and T cell-IFN-γ production while inhibiting TNF-α production by CD8(+) T cells. Lectin-like transcript 1 (LLT1), the ligand of CD161, was found to be… CONTINUE READING
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