Induction of laminitis by prolonged hyperinsulinaemia in clinically normal ponies.

@article{Asplin2007InductionOL,
  title={Induction of laminitis by prolonged hyperinsulinaemia in clinically normal ponies.},
  author={Katie E Asplin and M N Sillence and Christopher Charles Pollitt and C M Mcgowan},
  journal={Veterinary journal},
  year={2007},
  volume={174 3},
  pages={530-5}
}
The purpose of this study was to determine the effects of prolonged administration of insulin, whilst maintaining normal glucose concentrations, on hoof lamellar integrity in vivo on healthy ponies with no known history of laminitis or insulin resistance. Nine clinically healthy, unrelated ponies were randomly allocated to either a treatment group (n =5; 5.9+/-1.7 years) or control group (n =4; 7.0+/-2.8 years). The treatment group received insulin via a euglycaemic hyperinsulinaemic clamp… CONTINUE READING