Induction of keratinocyte proliferation and lymphocytic infiltration by in vivo introduction of the IL-6 gene into keratinocytes and possibility of keratinocyte gene therapy for inflammatory skin diseases using IL-6 mutant genes.

@article{Sawamura1998InductionOK,
  title={Induction of keratinocyte proliferation and lymphocytic infiltration by in vivo introduction of the IL-6 gene into keratinocytes and possibility of keratinocyte gene therapy for inflammatory skin diseases using IL-6 mutant genes.},
  author={Daisuke Sawamura and Xiangjun Meng and Shinsuke Ina and Marimo Sato and Katsuto Tamai and Katsumi Hanada and Isao Hashimoto},
  journal={Journal of immunology},
  year={1998},
  volume={161 10},
  pages={5633-9}
}
To understand biological function of IL-6 in the skin in vivo, we constructed a vector that strongly expressed human IL-6 in keratinocytes and introduced it into rat keratinocytes in vivo by the naked DNA method. The overexpression of IL-6 induced macroscopic erythema and histologically evident keratinocyte proliferation and lymphocytic infiltration in the treated area of rat skin. Since previous studies using IL-6 transgenic mice have not shown skin inflammation of these mice, our result… CONTINUE READING

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Since previous studies using IL-6 transgenic mice have not shown skin inflammation of these mice , our result provides the first evidence that IL-6 is related to the pathogenesis of inflammatory skin diseases .
Since previous studies using IL-6 transgenic mice have not shown skin inflammation of these mice , our result provides the first evidence that IL-6 is related to the pathogenesis of inflammatory skin diseases .
Since previous studies using IL-6 transgenic mice have not shown skin inflammation of these mice , our result provides the first evidence that IL-6 is related to the pathogenesis of inflammatory skin diseases .
Since previous studies using IL-6 transgenic mice have not shown skin inflammation of these mice , our result provides the first evidence that IL-6 is related to the pathogenesis of inflammatory skin diseases .
Since previous studies using IL-6 transgenic mice have not shown skin inflammation of these mice , our result provides the first evidence that IL-6 is related to the pathogenesis of inflammatory skin diseases .
Since previous studies using IL-6 transgenic mice have not shown skin inflammation of these mice , our result provides the first evidence that IL-6 is related to the pathogenesis of inflammatory skin diseases .
Since previous studies using IL-6 transgenic mice have not shown skin inflammation of these mice , our result provides the first evidence that IL-6 is related to the pathogenesis of inflammatory skin diseases .
Since previous studies using IL-6 transgenic mice have not shown skin inflammation of these mice , our result provides the first evidence that IL-6 is related to the pathogenesis of inflammatory skin diseases .
Since previous studies using IL-6 transgenic mice have not shown skin inflammation of these mice , our result provides the first evidence that IL-6 is related to the pathogenesis of inflammatory skin diseases .
Since previous studies using IL-6 transgenic mice have not shown skin inflammation of these mice , our result provides the first evidence that IL-6 is related to the pathogenesis of inflammatory skin diseases .
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