Induction of invasive carcinomas in the accessory sex organs other than the ventral prostate of rats given 3,2'-dimethyl-4-aminobiphenyl and testosterone propionate.

@article{Shirai1991InductionOI,
  title={Induction of invasive carcinomas in the accessory sex organs other than the ventral prostate of rats given 3,2'-dimethyl-4-aminobiphenyl and testosterone propionate.},
  author={Tomoyuki Shirai and Seiko Tamano and Taeko Kato and Shinji Iwasaki and Satoru Takahashi and Nobuyuki Ito},
  journal={Cancer research},
  year={1991},
  volume={51 4},
  pages={1264-9}
}
The promotion effects of testosterone propionate (TP) on prostate carcinogenesis were investigated in F344 rats given the prostatic carcinogen, 3,2'-dimethyl-4-aminobiphenyl (DMAB). One group of animals received s.c. DMAB injections at a dose of 50 mg/kg body weight at 2-week intervals for a total of 10 injections along with s.c. implantations of TP-containing Silastic tubes. A second experimental group of rats was given DMAB at the same dose and intervals but each injection of DMAB was… CONTINUE READING

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