Induction of intermediate mesoderm by retinoic acid receptor signaling from differentiating mouse embryonic stem cells.

@article{Oeda2013InductionOI,
  title={Induction of intermediate mesoderm by retinoic acid receptor signaling from differentiating mouse embryonic stem cells.},
  author={Shiho Oeda and Yohei Hayashi and Techuan Chan and Minoru Takasato and Yuko Aihara and Koji Okabayashi and Kiyoshi Ohnuma and Makoto Asashima},
  journal={The International journal of developmental biology},
  year={2013},
  volume={57 5},
  pages={
          383-9
        }
}
Renal lineages including kidney are derived from intermediate mesoderm, which are differentiated from a subset of caudal undifferentiated mesoderm. The inductive mechanisms of mammalian intermediate mesoderm and renal lineages are still poorly understood. Mouse embryonic stem cells (mESCs) can be a good in vitro model to reconstitute the developmental pathway of renal lineages and to analyze the mechanisms of the sequential differentiation. We examined the effects of Activin A and retinoic acid… CONTINUE READING

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