Induction of interleukin-6 expression by bone morphogenetic protein-6 in macrophages requires both SMAD and p38 signaling pathways.

@article{Lee2010InductionOI,
  title={Induction of interleukin-6 expression by bone morphogenetic protein-6 in macrophages requires both SMAD and p38 signaling pathways.},
  author={Geun Taek Lee and Seok Joo Kwon and Jae-Ho Lee and Seong Soo Jeon and Kee Taek Jang and Han Yong Choi and Hyun Moo Lee and W. -G. Kim and Seong Jin Kim and Isaac Yi Kim},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 50},
  pages={39401-8}
}
Unlike the prototype transforming growth factor-β (TGF-β), bone morphogenetic protein-6 (BMP-6) activates macrophages. Here, we report that BMP-6 induces the expression of IL-6 in macrophages. Using overexpression and knockdown experiments, we demonstrate that BMP receptor type II and activin-like kinase-2 are necessary for IL-6 induction by BMP-6. At the intracellular level, both Smad and p38 signaling pathways are required for the induction of IL-6. The cross-talk between the two pathways… CONTINUE READING

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