Induction of interleukin-1 beta mRNA and enkephalin mRNA in the rat adrenal gland by lipopolysaccharides studied by in situ hybridization histochemistry.

@article{Nobel1995InductionOI,
  title={Induction of interleukin-1 beta mRNA and enkephalin mRNA in the rat adrenal gland by lipopolysaccharides studied by in situ hybridization histochemistry.},
  author={Carolyn Nobel and Marianne Schultzberg},
  journal={Neuroimmunomodulation},
  year={1995},
  volume={2 2},
  pages={61-73}
}
Interleukin-1 is a macrophage-derived cytokine, which can also be synthesized in other cell types. It has been shown to exert several activities in the nervous and endocrine system, including a potent activating effect on the hypothalamo-pituitary-adrenal axis. High levels of interleukin-1 have previously been found in the adrenal gland. The effect of bacterial lipopolysaccharides (2.0 mg/kg) on interleukin-1 beta mRNA was studied in the rat adrenal gland by in situ hybridization histochemistry… CONTINUE READING
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