Induction of interferon-gamma, interleukin-4, and transforming growth factor-beta in rats orally tolerized against experimental autoimmune myasthenia gravis.

@article{Wang1994InductionOI,
  title={Induction of interferon-gamma, interleukin-4, and transforming growth factor-beta in rats orally tolerized against experimental autoimmune myasthenia gravis.},
  author={Zhen Yi Wang and Hans Link and A S Ljungdahl and Bo H{\"o}jeberg and John Link and Bai He and J Qiao and Arthur Melms and Tomas Olsson},
  journal={Cellular immunology},
  year={1994},
  volume={157 2},
  pages={353-68}
}
Oral administration of nicotinic acetylcholine receptor (AChR) to Lewis rats prior to myasthenogenic immunization with Torpedo AChR+complete Freund's adjuvant (CFA) results in the prevention of experimental autoimmune myasthenia gravis (EAMG) and the suppression of AChR-specific B cell responses and counteracts the development of AChR-reactive interferon-gamma (IFN-gamma) secreting T cells. To study the involvement of the T helper type 1 (Th1) cell-related lymphokine IFN-gamma, the Th2 cell… CONTINUE READING

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