Induction of innate immunity by lipid A mimetics increases survival from pneumonic plague.

@article{Airhart2008InductionOI,
  title={Induction of innate immunity by lipid A mimetics increases survival from pneumonic plague.},
  author={Christina L Airhart and Harold N Rohde and Gregory A. Bohach and Carolyn J. Hovde and Claudia F. Deobald and Stephen M. S. Lee and Scott A. Minnich},
  journal={Microbiology},
  year={2008},
  volume={154 Pt 7},
  pages={2131-8}
}
This study analysed the effect of priming the innate immune system using synthetic lipid A mimetics in a Yersinia pestis murine pulmonary infection model. Two aminoalkyl glucosaminide 4-phosphate (AGP) Toll-like receptor 4 (TLR4) ligands, delivered intranasally, extended time to death or protected against a lethal Y. pestis CO92 challenge. The level of protection was dependent upon the challenge dose of Y. pestis and the timing of AGP therapy. Protection correlated with cytokine induction and a… CONTINUE READING
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