Induction of innate immune responses by Escherichia coli and purified lipopolysaccharide correlate with organ- and cell-specific expression of Toll-like receptors within the human urinary tract.

@article{Bckhed2001InductionOI,
  title={Induction of innate immune responses by Escherichia coli and purified lipopolysaccharide correlate with organ- and cell-specific expression of Toll-like receptors within the human urinary tract.},
  author={Fredrik B{\"a}ckhed and Mats S{\"o}derh{\"a}ll and Paivi Ekman and Staffan J. Normark and Agneta Richter-Dahlfors},
  journal={Cellular microbiology},
  year={2001},
  volume={3 3},
  pages={
          153-8
        }
}
Mucosal epithelial linings function as physical barriers against microbes. In addition, they participate in the first line of host defence by production of a variety of proinflammatory mediators when exposed to microbes and microbial agents. Here, we use a human urinary tract infection model to demonstrate that organ- and cell-specific innate responses induced by lipopolysaccharides (LPS) present on Gram-negative bacteria correlates with the expression of Toll-like receptor 4 (TLR4). The… CONTINUE READING
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