Induction of innate immune response through TLR2 and dectin 1 prevents type 1 diabetes.

@article{KarumuthilMelethil2008InductionOI,
  title={Induction of innate immune response through TLR2 and dectin 1 prevents type 1 diabetes.},
  author={Subha Karumuthil-Melethil and Nicol{\'a}s P{\'e}rez and Ruobing Li and Chenthamarakshan Vasu},
  journal={Journal of immunology},
  year={2008},
  volume={181 12},
  pages={8323-34}
}
Studies have suggested a correlation between the decline in infectious diseases and increase in the incidence of type 1 diabetes (T1D) in developed countries. Pathogens influence the disease outcome through innate immune receptors such as TLRs. Here we report the effect of ligation of TLR2 and dectin 1 on APCs and the influence of innate immune response induced through these receptors on T1D. Exposure of APCs of NOD mice to zymosan, a fungal cell wall component that interacts with TLR2 and… CONTINUE READING

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