Induction of inducible nitric oxide synthase expression by neopterin in vascular smooth muscle cells.

@article{Schobersberger1995InductionOI,
  title={Induction of inducible nitric oxide synthase expression by neopterin in vascular smooth muscle cells.},
  author={Wolfgang Schobersberger and Georg Hoffmann and J{\"u}rgen Grote and Helmut Wachter and Dietmar Fuchs},
  journal={FEBS letters},
  year={1995},
  volume={377 3},
  pages={461-4}
}
The pteridine compounds neopterin and 7,8-dihydroneopterin serve as valuable indicators for the stimulation of the cellular immune system. Whether they exhibit distinct biochemical functions in the immunological process is at present under discussion. We show that neopterin, but not 7,8-dihydroneopterin, is a stimulus for iNOS gene expression in rat vascular smooth muscle cells in vitro. At a concentration of 20 microM, neopterin leads to an iNOS mRNA expression of 2.5 amol iNOS cDNA/micrograms… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

Similar Papers

Loading similar papers…