Induction of indoleamine 2,3-dioxygenase: a mechanism of the antitumor activity of interferon gamma.

@article{Ozaki1988InductionOI,
  title={Induction of indoleamine 2,3-dioxygenase: a mechanism of the antitumor activity of interferon gamma.},
  author={Yasuhiko Ozaki and Michal Edelstein and David S. Duch},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1988},
  volume={85 4},
  pages={1242-6}
}
The antiproliferative effects of interferon alpha (IFN-alpha) and interferon gamma (IFN-gamma) were found to be cell-dependent. Among the human cell lines examined, IFN-gamma had a greater antiproliferative effect against cell lines that exhibited induction of indoleamine 2,3-dioxygenase, such as the KB oral carcinoma or WiDr colon adenocarcinoma, than against those that lacked the enzyme activity, such as the SW480 colon adenocarcinoma or NCI-H128 small-cell lung carcinoma. Induction of this… CONTINUE READING
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