Induction of in vitro graft-versus-leukemia activity following bone marrow transplantation for chronic myeloid leukemia.

@article{Mackinnon1990InductionOI,
  title={Induction of in vitro graft-versus-leukemia activity following bone marrow transplantation for chronic myeloid leukemia.},
  author={Sharon Mackinnon and Jill M Hows and JohnM. Goldman},
  journal={Blood},
  year={1990},
  volume={76 10},
  pages={
          2037-45
        }
}
We studied the in vitro effects of lymphokine-activated killer (LAK) cells from the peripheral blood of chronic myeloid leukemia (CML) patients after allogeneic and syngeneic bone marrow transplantation (BMT). LAK cells were generated by incubating peripheral blood mononuclear cells from patients post-BMT with recombinant interleukin-2 (IL-2) (500 U/mL) in 10% AB serum for 7 days. They were phenotyped and tested for activity in a standard 4-hour 51Cr release assay (n = 37) and in a CFU-GM assay… CONTINUE READING

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Can graft-versus-leukemia reactivity be dissociated from graft-versus-host disease?

  • Frontiers in bioscience : a journal and virtual library
  • 2007
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