Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I.

Abstract

Bright/ARID3a/Dril1, a member of the ARID family of transcription factors, is expressed in a highly regulated fashion in B lymphocytes, where it enhances immunoglobulin transcription three- to sixfold. Recent publications from our lab indicated that functional, but not kinase-inactive, Bruton's tyrosine kinase (Btk) is critical for Bright activity in an in… (More)

Topics

  • Presentations referencing similar topics