Induction of immunogenic cell death by chemotherapeutic platinum complexes.

@article{Wong2015InductionOI,
  title={Induction of immunogenic cell death by chemotherapeutic platinum complexes.},
  author={Daniel Yuan Qiang Wong and Wendy Wei Fang Ong and Wee Han Ang},
  journal={Angewandte Chemie},
  year={2015},
  volume={54 22},
  pages={6483-7}
}
There is compelling evidence suggesting that the immune-modulating effects of many conventional chemotherapeutics, including platinum-based agents, play a crucial role in achieving clinical response. One way in which chemotherapeutics can engage a tumor-specific immune response is by triggering an immunogenic mode of tumor cell death (ICD), which then acts as an "anticancer vaccine". In spite of being a mainstay of chemotherapy, there has not been a systematic attempt to screen both existing… CONTINUE READING