Induction of immunity with avirulent Listeria monocytogenes 19113 depends on bacterial replication.

@article{Baldridge1988InductionOI,
  title={Induction of immunity with avirulent Listeria monocytogenes 19113 depends on bacterial replication.},
  author={Jory R. Baldridge and Michael F Thomashow and David John Hinrichs},
  journal={Infection and immunity},
  year={1988},
  volume={56 8},
  pages={
          2109-13
        }
}
Events necessary for triggering the cell-mediated response to intracellular parasites are poorly understood. Here we show that extremely high doses of avirulent Listeria monocytogenes 19113 (greater than 10(9] induce a modest and short-lived state of resistance in BALB/c mice. Induction of this protective state could not be achieved with nonviable bacteria and was blocked by inhibiting replication of viable L. monocytogenes 19113 through antibiotic treatment. The immune response was antigen… CONTINUE READING

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