Induction of immune responses to bovine herpesvirus type 1 gD in passively immune mice after immunization with a DNA-based vaccine.
@article{Lewis1999InductionOI,
title={Induction of immune responses to bovine herpesvirus type 1 gD in passively immune mice after immunization with a DNA-based vaccine.},
author={P. J. Lewis and van Drunen Littel-van den Hurk and Lorne A. Babiuk},
journal={The Journal of general virology},
year={1999},
volume={80 ( Pt 11)},
pages={
2829-37
}
}The potential for plasmids encoding a secreted form of bovine herpesvirus type 1 (BHV-1) glycoprotein D (gD) to elicit immune responses in passively immune mice following intramuscular immunization was investigated. In these experiments, 6- to 8-week-old female C3H/HeN or C57BL/6 mice were passively immunized with hyperimmune antisera raised against BHV-1 recombinant, truncated (secreted) gD immediately prior to immunization with plasmids. A single immunization of passively immune mice with…
31 Citations
Induction of immune responses in cattle with a DNA vaccine encoding glycoprotein C of bovine herpesvirus-1.
- Biology, MedicineVeterinary microbiology
- 2001
Biolistic-mediated gene transfer using the bovine herpesvirus-1 glycoprotein D is an effective delivery system to induce neutralizing antibodies in its natural host.
- Biology, MedicineJournal of immunological methods
- 2000
Use of Adjuvants to Enhance the Immune Response Induced by a DNA Vaccine Against Bovine Herpesvirus-1.
- BiologyViral immunology
- 2015
It was observed that a DNA vaccine with Montanide Essai 903110 induced the highest BoHV-1 specific IFN-γ production in cattle, and this adjuvant is proposed as a suitable candidate to be tested in a BoHv-1 DNA vaccine for protection against viral challenge in bovines.
Use of Adjuvants to Enhance the Immune Response Induced by a DNA Vaccine Against Bovine Herpesvirus-1.
- Biology, Engineering
- 2015
It was observed that a DNA vaccine with Montanide Essai 903110 induced the highest BoHV-1 specific IFN-γ production in cattle, and this adjuvant is proposed as a suitable candida response in the natural host.
Induction of humoral responses to BHV-1 glycoprotein D expressed by HSV-1 amplicon vectors
- BiologyJournal of veterinary science
- 2012
Findings reinforce previous findings that HSV-1 amplicon vectors can potentially deliver antigens to animals and highlight the prospective use of these vectors for treating infectious bovine rhinotracheitis disease.
Immunization with plasmid DNA encoding a truncated, secreted form of the bovine viral diarrhea virus E2 protein elicits strong humoral and cellular immune responses.
- BiologyVaccine
- 2005
Genetic immunisation of cattle against bovine herpesvirus 1: glycoprotein gD confers higher protection than glycoprotein gC or tegument protein VP8.
- BiologyVeterinary research
- 2005
It is demonstrated in cattle that a DNA vaccine encoding BoHV-1 glycoprotein gD induces higher neutralising antibody titres than vaccines encoding BoC and VP8 antigens, confirming the difficulty to develop efficient DNA vaccines in large species.
DNA vaccination against pseudorabies virus and bovine respiratory syncytial virus infections of young animals in the face of maternally derived immunity.
- BiologyJournal of comparative pathology
- 2007
Protection against very virulent infectious bursal disease virus in chickens immunized with DNA vaccines.
- BiologyVeterinary microbiology
- 2004
References
SHOWING 1-10 OF 55 REFERENCES
Immunogenicity of bovine herpesvirus 1 glycoprotein D in mice: effect of antigen form on the induction of cellular and humoral immune responses.
- BiologyViral immunology
- 1996
The results indicate that both gD and tgD are capable of efficiently inducing a cell-mediated immune response, and although recombinant t gD is less efficient in inducing a primary humoral immune response when compared to the full-length gD, tgG effectively primed for a secondary antibody response.
Neonatal DNA immunization with a plasmid encoding an internal viral protein is effective in the presence of maternal antibodies and protects against subsequent viral challenge
- BiologyJournal of virology
- 1997
It is demonstrated that mouse pups injected with the same plasmid hours or days after birth produce major histocompatibility complex-restricted, NP-specific cytotoxic T lymphocytes that persist into adulthood, suggesting that, at least in this model system, DNA immunization circumvents many of the problems associated with neonatal immunization.
DNA immunization of newborn mice with a plasmid-expressing nucleoprotein of influenza virus.
- Biology, MedicineViral immunology
- 1996
Mice immunized as neonates with NPV1 plasmid developed a protective cellular immune response, like the adult mice, and the strategy of DNA immunization may be considered for the purpose of human vaccination to prevent horizontally and vertically transmitted life-threatening infections in infants or children.
Genetic immunization of seronegative one-day-old piglets against pseudorabies induces neutralizing antibodies but not protection and is ineffective in piglets from immune dams.
- Biology, MedicineVeterinary research
- 1996
It can be concluded that genetic immunization was inefficient at efficiently preventing the immune response inhibition by colostral antibodies in piglets, as demonstrated by the antibodies kinetics after challenge.
Induction of neonatal tolerance by plasmid DNA vaccination of mice.
- BiologyThe Journal of clinical investigation
- 1996
It is found that the same DNA vaccine induces tolerance rather than immunity when administered to 2-5 d-old mice, demonstrating important differences in the nature and specificity of the immune response elicited by DNA vaccines versus conventional protein immunogens.
DNA-mediated immunization to hepatitis B surface antigen: longevity of primary response and effect of boost.
- BiologyVaccine
- 1996
Influence of maternal antibodies on vaccine responses: inhibition of antibody but not T cell responses allows successful early prime‐boost strategies in mice
- Biology, MedicineEuropean journal of immunology
- 1998
Very early priming and boosting with live measles vaccine is allowed to circumvent maternal antibody inhibition of antibody responses in pups of immune mothers, suggesting that effective vaccine responses may be obtained earlier in presence of maternal antibodies through the use of appropriate immunization strategies using conventional or novel vaccines forEarly priming.
Transfer of maternal antibodies results in inhibition of specific immune responses in the offspring
- Biology
- 1992
Influenza virus nucleoprotein-specific immunoglobulin G subclass and cytokine responses elicited by DNA vaccination are dependent on the route of vector DNA delivery
- BiologyJournal of virology
- 1996
These data show that intramuscular inoculation leads to Th1-like responses due to elevated IgG2a levels, production of gamma interferon, CTL activity, and lack of IL-4, consistent with the idea that the types of responses elicited following DNA immunization.




