Induction of immune responses to bovine herpesvirus type 1 gD in passively immune mice after immunization with a DNA-based vaccine.

@article{Lewis1999InductionOI,
  title={Induction of immune responses to bovine herpesvirus type 1 gD in passively immune mice after immunization with a DNA-based vaccine.},
  author={P. J. Lewis and van Drunen Littel-van den Hurk and Lorne A. Babiuk},
  journal={The Journal of general virology},
  year={1999},
  volume={80 ( Pt 11)},
  pages={
          2829-37
        }
}
The potential for plasmids encoding a secreted form of bovine herpesvirus type 1 (BHV-1) glycoprotein D (gD) to elicit immune responses in passively immune mice following intramuscular immunization was investigated. In these experiments, 6- to 8-week-old female C3H/HeN or C57BL/6 mice were passively immunized with hyperimmune antisera raised against BHV-1 recombinant, truncated (secreted) gD immediately prior to immunization with plasmids. A single immunization of passively immune mice with… 

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It was observed that a DNA vaccine with Montanide Essai 903110 induced the highest BoHV-1 specific IFN-γ production in cattle, and this adjuvant is proposed as a suitable candidate to be tested in a BoHv-1 DNA vaccine for protection against viral challenge in bovines.
Use of Adjuvants to Enhance the Immune Response Induced by a DNA Vaccine Against Bovine Herpesvirus-1.
TLDR
It was observed that a DNA vaccine with Montanide Essai 903110 induced the highest BoHV-1 specific IFN-γ production in cattle, and this adjuvant is proposed as a suitable candida response in the natural host.
Induction of humoral responses to BHV-1 glycoprotein D expressed by HSV-1 amplicon vectors
TLDR
Findings reinforce previous findings that HSV-1 amplicon vectors can potentially deliver antigens to animals and highlight the prospective use of these vectors for treating infectious bovine rhinotracheitis disease.
Genetic immunisation of cattle against bovine herpesvirus 1: glycoprotein gD confers higher protection than glycoprotein gC or tegument protein VP8.
TLDR
It is demonstrated in cattle that a DNA vaccine encoding BoHV-1 glycoprotein gD induces higher neutralising antibody titres than vaccines encoding BoC and VP8 antigens, confirming the difficulty to develop efficient DNA vaccines in large species.
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