Induction of immediate-early genes c-fos and zif268 in the subnucleus oralis by noxious tooth pulp stimulation.

@article{Sugimoto1998InductionOI,
  title={Induction of immediate-early genes c-fos and zif268 in the subnucleus oralis by noxious tooth pulp stimulation.},
  author={Tomosada Sugimoto and Yun Feng He and Makoto Funahashi and Hiroyuki Ichikawa},
  journal={Brain research},
  year={1998},
  volume={794 2},
  pages={353-8}
}
c-fos and zif268 expression were assessed by immunocytochemistry for c-Fos and Zif268 proteins in the sensory trigeminal nuclear complex following noxious mechanical stimulation of the mandibular incisor pulp of rats. Marked up-regulation of both immediate early genes was observed in the subnucleus oralis ipsilateral to the stimulation. Cavity preparation of the dentine without reaching the pulp did not cause significant up-regulation detectable by immunocytochemistry. These results provide… CONTINUE READING