Induction of hypoxia-inducible factor 1alpha gene expression by vascular endothelial growth factor.

@article{Deudero2008InductionOH,
  title={Induction of hypoxia-inducible factor 1alpha gene expression by vascular endothelial growth factor.},
  author={Juan Jose Deudero and Carlos A. Caramelo and Mar{\'i}a del Carmen Castellanos and Fernando Neria and Ruth Fern{\'a}ndez-S{\'a}nchez and Olalla Calabia and S. Arencibia Pe{\~n}ate and Francisco Rom{\'a}n Gonz{\'a}lez-Pacheco},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 17},
  pages={
          11435-44
        }
}
Transcriptional regulation of vascular endothelial growth factor (VEGF) is critically dependent on hypoxia-inducible factor 1 (HIF-1). However, not only hypoxia, but selected growth factors can induce HIF-1. High levels of both VEGF and HIF-1 coexist in certain conditions, e.g. tumors. Nonetheless, the possibility that the stimulatory relationship between HIF-1 and VEGF may be bi-directional has not been addressed up to date. The present study in endothelial cells analyzed whether HIF-1 is… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 18 CITATIONS

Resistance to EGF-R (erbB-1) and VEGF-R modulating agents.

  • European journal of cancer
  • 2009
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Oxidative stress induced cellular signaling in RPE cells.

  • Frontiers in bioscience
  • 2012
VIEW 1 EXCERPT
CITES BACKGROUND

Studies on Retinal and Choroidal Disorders

  • Oxidative Stress in Applied Basic Research and Clinical Practice
  • 2012

References

Publications referenced by this paper.

VEGF Induction of HIF-1 through Superoxide 11444 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

A. L. Harris
  • Nat. Rev. Cancer
  • 2002
VIEW 1 EXCERPT