Induction of hypertension and peripheral inflammation by reduction of extracellular superoxide dismutase in the central nervous system.

@article{Lob2010InductionOH,
  title={Induction of hypertension and peripheral inflammation by reduction of extracellular superoxide dismutase in the central nervous system.},
  author={Heinrich E. Lob and Paul J. Marvar and Tomasz J. Guzik and Shraya Sharma and Louise A. McCann and Cornelia M Weyand and Frank J Gordon and David G Harrison},
  journal={Hypertension},
  year={2010},
  volume={55 2},
  pages={277-83, 6p following 283}
}
The circumventricular organs (CVOs) lack a well-formed blood-brain barrier and produce superoxide in response to angiotensin II and other hypertensive stimuli. This increase in central superoxide has been implicated in the regulation of blood pressure. The extracellular superoxide dismutase (SOD3) is highly expressed in cells associated with CVOs and… CONTINUE READING