Induction of hypergammaglobulinemia and macrophage activation by silicone gels and oils in female A.SW mice.

@article{Naim2000InductionOH,
  title={Induction of hypergammaglobulinemia and macrophage activation by silicone gels and oils in female A.SW mice.},
  author={John Naim and Minoru Satoh and Norene A. Buehner and Kim Ippolito and Hideki Yoshida and David J Nusz and L Kurtelawicz and Stewart F Cramer and Westley H. Reeves},
  journal={Clinical and diagnostic laboratory immunology},
  year={2000},
  volume={7 3},
  pages={366-70}
}
Although most published epidemiological studies have found little evidence of systemic autoimmune disease associated with silicone breast implants, there still remains a question of whether silicones can cause local and/or systemic immune dysfunction. This study further investigates the effects of silicones on autoantibody and immunoglobulin production and macrophage activation in female A.SW mice. Sixty mice were divided among four treatment groups receiving a 0.5-ml intraperitoneal injection… CONTINUE READING
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