Induction of humoral and cellular immune responses to the human immunodeficiency type 1 virus in nonhuman primates by in vivo DNA inoculation.

@article{Wang1995InductionOH,
  title={Induction of humoral and cellular immune responses to the human immunodeficiency type 1 virus in nonhuman primates by in vivo DNA inoculation.},
  author={Bingxiang Wang and Jean D. Boyer and Vasantha Srikantan and Kenneth E Ugen and Lori Gilbert and Cindy Phan and Kesen Dang and M M Merva and Michael G. Agadjanyan and Mark Newman},
  journal={Virology},
  year={1995},
  volume={211 1},
  pages={102-12}
}
DNA inoculation has the potential to produce antigens in a native as well as a host-"customized" form for presentation to the immune system. As such this technology may have relevance for vaccine/immune therapeutic strategies for a variety of infectious pathogens. In rodents in vivo inoculation of plasmid expression vectors encoding HIV-1 gene products leads to production of HIV-1 antigens in vivo, resulting in the production of both cellular and humoral immune responses. In primates only… CONTINUE READING
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