Induction of human matrix metalloproteinase-12 gene transcriptional activity by GM-CSF requires the AP-1 binding site in human U937 monocytic cells.

Abstract

Matrix metalloproteinase-12 (MMP-12) is critical for the migration of monocytes/macrophages into inflammatory sites through the basement membranes. We previously reported that MMP-12 expression was initially induced by granulocyte macrophage colony-stimulating factor (GM-CSF) in human peripheral blood monocytes and U937 monocytic cells. To further elucidate… (More)

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@article{Wu2001InductionOH, title={Induction of human matrix metalloproteinase-12 gene transcriptional activity by GM-CSF requires the AP-1 binding site in human U937 monocytic cells.}, author={Lian Wu and Akihide Tanimoto and Yuji Murata and J. Fan and Yasuyuki Sasaguri and T Watanabe}, journal={Biochemical and biophysical research communications}, year={2001}, volume={285 2}, pages={300-7} }