Induction of human CD4+ regulatory T cells by mycophenolic acid-treated dendritic cells.

@article{Lagaraine2008InductionOH,
  title={Induction of human CD4+ regulatory T cells by mycophenolic acid-treated dendritic cells.},
  author={Christine Lagaraine and Roxane Lemoine and Christophe Baron and Hubert Nivet and Florence Velge-Roussel and Yvon Lebranchu},
  journal={Journal of leukocyte biology},
  year={2008},
  volume={84 4},
  pages={1057-64}
}
Depending on their degree of maturation, costimulatory molecule expression, and cytokine secretion, dendritic cells (DC) can induce immunity or tolerance. DC treated with mycophenolic acid during their maturation (MPA-DC) have a regulatory phenotype and may therefore provide a new approach to induce allograft tolerance. Purified CD4(+) T cells stimulated in… CONTINUE READING