Induction of histone deacetylases (HDACs) in human abdominal aortic aneurysm: therapeutic potential of HDAC inhibitors

@inproceedings{Galn2016InductionOH,
  title={Induction of histone deacetylases (HDACs) in human abdominal aortic aneurysm: therapeutic potential of HDAC inhibitors},
  author={Mar{\'i}a Gal{\'a}n and Saray Varona and Mar Orriols and Jose Antonio Rodr{\'i}guez and Silvia Aguil{\'o} and Jaume F Dilme and Mercedes Camacho and Jos{\'e} L Mart{\'i}nez-Gonz{\'a}lez and Cristina Rodr{\'i}guez},
  booktitle={Disease models & mechanisms},
  year={2016}
}
Clinical management of abdominal aortic aneurysm (AAA) is currently limited to elective surgical repair because an effective pharmacotherapy is still awaited. Inhibition of histone deacetylase (HDAC) activity could be a promising therapeutic option in cardiovascular diseases. We aimed to characterise HDAC expression in human AAA and to evaluate the therapeutic potential of class I and IIa HDAC inhibitors in the AAA model of angiotensin II (Ang II)-infused apolipoprotein-E-deficient (ApoE… CONTINUE READING