Induction of hippocampal neurogenesis by a tolerogenic peptide that ameliorates lupus manifestations.

@article{Telerman2011InductionOH,
  title={Induction of hippocampal neurogenesis by a tolerogenic peptide that ameliorates lupus manifestations.},
  author={Alona Telerman and Smadar Lapter and Amir Sharabi and Heidy Zinger and Edna Mozes},
  journal={Journal of neuroimmunology},
  year={2011},
  volume={232 1-2},
  pages={151-7}
}
To determine the effect of the tolerogenic peptide hCDR1 on hippocampal neurogenesis, we treated SLE-afflicted (NZBxNZW)F1 mice with hCDR1 (once a week for 10weeks). The treatment resulted in the up-regulation of neurogenesis in the dentate gyrus and restored the NeuN immunoreactivity in brain hippocampi of the mice in association with increased gene expression of IGF-1, NGF and BDNF. Furthermore, hCDR1 treatment significantly up-regulated p-ERK and p-Akt that are suggested to be key components… CONTINUE READING