Induction of high mobility group-I(Y) protein by endotoxin and interleukin-1beta in vascular smooth muscle cells. Role in activation of inducible nitric oxide synthase.

@article{Pellacani1999InductionOH,
  title={Induction of high mobility group-I(Y) protein by endotoxin and interleukin-1beta in vascular smooth muscle cells. Role in activation of inducible nitric oxide synthase.},
  author={Andrea Pellacani and Michael T. Chin and Philippe Wiesel and Miguel Mart{\'i}n-Luquero Ib{\'a}{\~n}ez and Adarsh Patel and S F Yet and Chuen M. Hsieh and Joseph D. Paulauskis and Raymond Reeves and Margaret E. Lee and Mark A. Perrella},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 3},
  pages={1525-32}
}
Nonhistone chromosomal proteins of the high mobility group (HMG) affect the transcriptional regulation of certain mammalian genes. For example, HMG-I(Y) controls cytokine-mediated promoters that require transcription factors, such as nuclear factor-kappaB, for maximal expression. Even though a great deal is known about how HMG-I(Y) facilitates expression of other genes, less is known about the regulation of HMG-I(Y) itself, especially in cells in primary culture. Therefore we investigated the… CONTINUE READING