Induction of high incidence of mammary tumour in female Noble rats with a combination of 17beta-oestradiol and testosterone.

@article{Xie1999InductionOH,
  title={Induction of high incidence of mammary tumour in female Noble rats with a combination of 17beta-oestradiol and testosterone.},
  author={Benjamin Xie and Sai Wah Tsao and Yong Chuan Wong},
  journal={Carcinogenesis},
  year={1999},
  volume={20 6},
  pages={
          1069-78
        }
}
Breast cancer is the most common cancer and the second most frequent cause of cancer death in women. Despite extensive research, the precise mechanisms of breast carcinogenesis remain unclear. One of the reasons for this is due, at least in part, to a lack of a suitable animal model which can closely mimic the breast carcinogenesis in normal situations without using chemical carcinogens. We have developed an animal model of mammary gland carcinogenesis using a combination of oestradiol and… CONTINUE READING
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