Induction of hepatocyte growth factor production in human dermal fibroblasts and their proliferation by the extract of bitter melon pulp.

@article{Ono2009InductionOH,
  title={Induction of hepatocyte growth factor production in human dermal fibroblasts and their proliferation by the extract of bitter melon pulp.},
  author={Takehiro Ono and Tsutomu Tsuji and Miho Sakai and Chizuko Yukizaki and Hisatoshi Ino and Isao Akagi and Kaori Hiramatsu and Yohsuke Matsumoto and Yoshihiro Sugiura and Hirofumi Uto and Hirohito Tsubouchi and Eiichi Gohda},
  journal={Cytokine},
  year={2009},
  volume={46 1},
  pages={
          119-26
        }
}
Hepatocyte growth factor (HGF) is useful as a potential therapeutic agent for hepatic and renal fibrosis and cardiovascular diseases through inducing proliferation of epithelial and endothelial cells. HGF inducers may also be useful as therapeutic agents for these diseases. However, there have been no reports on induction of HGF production by plant extracts or juices. An extract of bitter melon (Momordica charantia L.) pulp markedly induced HGF production. There was a time lag of 72 h before… CONTINUE READING

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