Induction of hepatocyte growth factor/scatter factor by fibroblast clustering directly promotes tumor cell invasiveness.

@article{Kankuri2005InductionOH,
  title={Induction of hepatocyte growth factor/scatter factor by fibroblast clustering directly promotes tumor cell invasiveness.},
  author={Esko Kankuri and Dana Cholujov{\'a} and Monika Comajova and Antti Vaheri and Jozef B{\'i}zik},
  journal={Cancer research},
  year={2005},
  volume={65 21},
  pages={9914-22}
}
For determining the malignant behavior of a tumor, paracrine interactions between stromal and cancer cells are crucial. We previously reported that fibroblast clustering induces cyclooxygenase-2 (COX-2), plasminogen activation, and programmed necrosis, all of which were significantly reduced by nonsteroidal anti-inflammatory drugs (NSAID). We have now found that tumor cell-conditioned medium induces similar fibroblast clustering. Activation of the necrotic pathway in clustering fibroblasts… CONTINUE READING

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We previously reported that fibroblast clustering induces cyclooxygenase-2 ( COX-2 ) , plasminogen activation , and programmed necrosis , all of which were significantly reduced by nonsteroidal anti - inflammatory drugs ( NSAID ) .
We previously reported that fibroblast clustering induces cyclooxygenase-2 ( COX-2 ) , plasminogen activation , and programmed necrosis , all of which were significantly reduced by nonsteroidal anti - inflammatory drugs ( NSAID ) .
Induction of hepatocyte growth factor / scatter factor by fibroblast clustering directly promotes tumor cell invasiveness .
Induction of hepatocyte growth factor / scatter factor by fibroblast clustering directly promotes tumor cell invasiveness .
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