Induction of hepatocyte growth by intraportal infusion of HGF into beagle dogs.

@article{Kobayashi1996InductionOH,
  title={Induction of hepatocyte growth by intraportal infusion of HGF into beagle dogs.},
  author={Yoshinori Kobayashi and Masahiro Hamanoue and Susumu Ueno and Takashi Aikou and Gen Tanabe and Shinji Mitsue and Kazuya Matsumoto and Tomoyuki Nakamura},
  journal={Biochemical and biophysical research communications},
  year={1996},
  volume={220 1},
  pages={7-12}
}
Hepatocyte growth factor (HGF), originally identified as a potent mitogen for mature parenchymal hepatocytes, is a hepatotrophic factor involved in liver regeneration and is even essential for development of the liver. We report here that human recombinant HGF at a very low concentration and given intraportaly stimulated liver regeneration in dogs. In vitro, HGF dose-dependently stimulated DNA synthesis of primary cultured hepatocytes isolated from a dog. The maximal activity was twofold higher… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

Review: Research Toward Safer Resection of the Cirrhotic Liver

HPB surgery : a world journal of hepatic, pancreatic and biliary surgery • 2000

Similar Papers

Loading similar papers…