Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide.

  title={Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide.},
  author={Emilio A. Emini and Joseph V. Hughes and Debbie S Perlow and Joshua Boger},
  journal={Journal of virology},
  volume={55 3},
Comparative surface feature analyses of the VP1 sequences of hepatitis A virus (HAV) and poliovirus type 1 allowed an alignment of the two sequences and an identification of probable HAV neutralization antigenic sites. A synthetic peptide containing the HAV-specific amino acid sequence of one of these sites induced anti-HAV-neutralizing antibodies. It is concluded that a structural homology exists between the two viruses, despite minimal primary sequence conservation. 
Highly Influential
This paper has highly influenced 17 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
265 Citations
18 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 265 extracted citations


Publications referenced by this paper.
Showing 1-10 of 18 references

Molecular cloning and partial sequencing of hepatitis A viral cDNA

  • F.-T. Liu, M. Zinnecker, T. Hamaoka, D. H. Katz
  • J . Virol .
  • 1985

Molecular cloning and characterization of hepatitis A virus cDNA

  • G. Walter, K. H. Scheidtmann, A. Carbone, A. P. Laudano, R. F. Doolittle
  • Proc . Natl . Acad . Sci . U . S . A .
  • 1983

Molecular cloning of poliovirus cDNA and determination of the complete nucleotide sequence of the viral genome

  • G. Siegi, G. G. Frosner, J. D. Tratschin V. Gauss-Muller, F. Deinhardt
  • Proc . Natl . Acad . Sci . U . S . A .
  • 1981

Similar Papers

Loading similar papers…