Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide.

@article{Emini1985InductionOH,
  title={Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide.},
  author={Emilio A. Emini and Joseph V. Hughes and Debbie S Perlow and Joshua Boger},
  journal={Journal of virology},
  year={1985},
  volume={55 3},
  pages={836-9}
}
Comparative surface feature analyses of the VP1 sequences of hepatitis A virus (HAV) and poliovirus type 1 allowed an alignment of the two sequences and an identification of probable HAV neutralization antigenic sites. A synthetic peptide containing the HAV-specific amino acid sequence of one of these sites induced anti-HAV-neutralizing antibodies. It is concluded that a structural homology exists between the two viruses, despite minimal primary sequence conservation. 
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Molecular cloning of poliovirus cDNA and determination of the complete nucleotide sequence of the viral genome

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