Induction of hepatic microsomal cytochrome P450 and drug-metabolizing enzymes by 4-benzylpyridine and its structurally related compounds in rats. Dose- and sex-related differential induction of cytochrome P450 species.

@article{Kobayashi1992InductionOH,
  title={Induction of hepatic microsomal cytochrome P450 and drug-metabolizing enzymes by 4-benzylpyridine and its structurally related compounds in rats. Dose- and sex-related differential induction of cytochrome P450 species.},
  author={Yasuna Kobayashi and Yukinaga Matsuura and Eiji Kotani and Toshihiro Iio and Tatsuo Fukuda and Takaaki Aoyagi and Seisho Tobinaga and Takayuki Yoshida and Yuichi Kuroiwa},
  journal={Biochemical pharmacology},
  year={1992},
  volume={43 10},
  pages={2151-9}
}
We examined the abilities of 4-, 3- and 2-benzylpyridine and 4-tert-butylpyridine to induce hepatic microsomal cytochrome P450 and drug-metabolizing enzymes in male and female rats in order to define the effects of pyridine-containing compounds on drug metabolism. 4-Benzylpyridine (0.4 mmol/kg, for 2 consecutive days) induced total cytochrome P450 to about three times that of the controls at 24 hr, and its inducing effect was sustained for 120 hr after the treatment in male and female rats. 4… CONTINUE READING

From This Paper

Topics from this paper.

Similar Papers

Loading similar papers…