Induction of hepatic glutathione S-transferases in male mice by prototypes of various classes of microsomal enzyme inducers.

@article{Knight2008InductionOH,
  title={Induction of hepatic glutathione S-transferases in male mice by prototypes of various classes of microsomal enzyme inducers.},
  author={Tamara Raphael Knight and Supratim Choudhuri and Curtis D. Klaassen},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2008},
  volume={106 2},
  pages={329-38}
}
The underlying need for glutathione S-transferase (Gst) induction is thought to be an adaptive response to chemical stress within the cell. Classical microsomal enzyme inducers (MEIs) increase the expression of biotransformation enzymes (phase I and II) and transporters through transcription factors, such as the aryl hydrocarbon receptor (AhR), constitutive androstane receptor (CAR), pregnane X receptor (PXR), peroxisome proliferator-activated receptor (PPAR) alpha, and nuclear factor erythroid… CONTINUE READING
25 Citations
40 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 40 references

Similar Papers

Loading similar papers…