Induction of hepatic enzyme synthesis in vivo by adenosine 3', 5'-monophosphate.

@article{Wicks1969InductionOH,
  title={Induction of hepatic enzyme synthesis in vivo by adenosine 3', 5'-monophosphate.},
  author={Wesley D. Wicks and Francis T. Kenney and Kian Leong Lee},
  journal={The Journal of biological chemistry},
  year={1969},
  volume={244 21},
  pages={6008-13}
}
The N6,02’-dibutyryl analogue of cyclic adenosine 3’,5’monophosphate (dibutyryl cyclic AMP) elevates the level of hepatic tyrosine-cr-ketoglutarate transaminase (L-tyrosine: 2-oxoglutarate aminotransferase, EC 2.6.1.5) some 3to 6-fold in intact and adrenalectomized rats. The response of this enzyme is more rapid to dibutyryl cyclic AMP than to any other inducer of the transaminase. Hourly injection of dibutyryl cyclic AMP can maintain the elevated transaminase level for at least 5 hours. The… CONTINUE READING