Induction of hepatic enzyme synthesis in vivo by adenosine 3', 5'-monophosphate.

@article{Wicks1969InductionOH,
  title={Induction of hepatic enzyme synthesis in vivo by adenosine 3', 5'-monophosphate.},
  author={Wesley D. Wicks and F. T. Kenney and Kian Leong Lee},
  journal={The Journal of biological chemistry},
  year={1969},
  volume={244 21},
  pages={6008-13}
}
The N6,02’-dibutyryl analogue of cyclic adenosine 3’,5’monophosphate (dibutyryl cyclic AMP) elevates the level of hepatic tyrosine-cr-ketoglutarate transaminase (L-tyrosine: 2-oxoglutarate aminotransferase, EC 2.6.1.5) some 3to 6-fold in intact and adrenalectomized rats. The response of this enzyme is more rapid to dibutyryl cyclic AMP than to any other inducer of the transaminase. Hourly injection of dibutyryl cyclic AMP can maintain the elevated transaminase level for at least 5 hours. The… CONTINUE READING
Highly Cited
This paper has 43 citations. REVIEW CITATIONS
10 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Heme and Hemoproteins

  • Contributors, ' K.WBock, +13 authors Tschudy
  • Handbuch der experimentellen Pharmakologie…
  • 1978

Similar Papers

Loading similar papers…