Induction of heparin-binding growth-associated molecule expression in reactive astrocytes following hippocampal neuronal injury
@article{Takeda1995InductionOH, title={Induction of heparin-binding growth-associated molecule expression in reactive astrocytes following hippocampal neuronal injury}, author={Atsushi Takeda and Hiroshi Onodera and Akira Sugimoto and Yasuo Itoyama and Kyuya Kogure and Heikki Rauvala and Shigeki Shibahara}, journal={Neuroscience}, year={1995}, volume={68}, pages={57-64} }
52 Citations
Induction of Midkine Expression in Reactive Astrocytes Following Rat Transient Forebrain Ischemia
- BiologyExperimental Neurology
- 1998
The changes of MK expression in the adult rat brain following transient forebrain ischemia are examined by Northern blot, in situ hybridization and immunohistochemical analyses, suggesting that MK may be an insult-induced molecule which participates in the reparative processes following neuronal injury.
Increased synthesis of heparin affin regulatory peptide in the perforant path lesioned mouse hippocampal formation
- BiologyExperimental Brain Research
- 2000
Investigation of the expression of HARP mRNA and protein in the perforant path lesioned C57Bl/6 mouse hippocampal formation from 1 to 35 days after surgery found that Harp mRNA is expressed in neurons and white and gray matter glial cells as well as vascular and pial cells throughout the normal, adult brain.
Upregulation of heparin-binding growth-associated molecule after spinal cord injury in adult rats.
- Biology, MedicineActa pharmacologica Sinica
- 2004
Both neurons and glial cells expressed HB-GAM implying that HB- GAM played a role in the process of injury and/or repair following SCI.
Heparin-Binding Growth-Associated Molecule (Pleiotrophin) Affects Sensory Signaling and Selected Motor Functions in Mouse Model of Anatomically Incomplete Cervical Spinal Cord Injury
- BiologyFrontiers in Neurology
- 2021
Recovery of sensory signaling in the sensorimotor cortex by HB-GAM to the level of sham-operated mice may contribute to the improvement of skilled locomotion requiring integration of spatiotemporal signals in the somatosensory cortex.
HB-GAM (HEPARIN-BINDING GROWTH-ASSOCIATED MOLECULE) AND HEPARIN-TYPE GLYCANS IN THE DEVELOPMENT AND PLASTICITY OF NEURON-TARGET CONTACTS
- BiologyProgress in Neurobiology
- 1997
Midkine expression in transient retinal ischemia in the rat.
- BiologyCurrent eye research
- 1998
Ex vivo endogenous MK responds to ischemic treatment by an initial decrease in expression and then a period of expression above basal levels, which became more abundant after pressure-induced retinal ischemia.
Role of Heparin-Binding Growth-Associated Molecule (HB-GAM) in Hippocampal LTP and Spatial Learning Revealed by Studies on Overexpressing and Knockout Mice
- Biology, PsychologyMolecular and Cellular Neuroscience
- 2002
Results show that HB-GAM suppresses LTP in hippocampus and plays a role in regulation of learning-related behavior.
Transient expression of juvenile-type neurocan by reactive astrocytes in adult rat brains injured by kainate-induced seizures as well as surgical incision
- BiologyNeuroscience
- 2002
Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's disease
- BiologyBrain Research
- 2007
Inhibition and enhancement of neural regeneration by chondroitin sulfate proteoglycans
- BiologyNeural regeneration research
- 2017
In vivo studies using two-photon imaging after local HB-GAM injection into prick-injury of the cerebral cortex reveal regeneration of dendrites that has not been previously demonstrated after injuries of the mammalian nervous system.
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